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Pyroluria/Pyrrol Disorder

Stressed Woman
 Young Woman Contemplating

What is Pyroluria? 


Pyroluria is sometimes called Pyrrole disorder or Kryptopyrroles syndrome.

Pyroluria is a genetic condition of haemoglobin metabolism, in which an individual produces a large number of Kryptopyrroles which attach themselves to zinc and vitamin B6 and prevent them from being used by the body. The cause of the condition is predominantly genetic; however, severe oxidative stress, poor diet or other underlying digestive issues problems can be the trigger. Illness, trauma, injuries, toxic metals, pesticides, industrial pollutants significantly increase oxidative stress. High level of stress may also contribute to this condition. The resulting deficiencies of vital nutrients of vitamin B6 and zinc may cause a myriad of symptoms. 

Some patients have symptoms during childhood and are then often categorized as ADD/ADHD. Others can develop a variety of mood and/or behavioural syndromes over time.


What are the symptoms of Pyrroluria?


  • Anxiety, nervous exhaustion

  • Abnormal body fat distribution (fat around the middle)

  • Abdominal pain/spleen region

  • Affinity for spicy food/Intense food

  • Acne

  • Allergies

  • Anger – explosive

  • Argumentative / angry

  • Brain Fog, poor short term memory

  • Broods/ overthinks

  • Constipation

  • Creaking in joints

  • Delusions

  • Depression

  • Dramatic

  • Dry skin/psoriasis

  • Dyslexia

  • Early greying of hair

  • Eczema

  • Emotionally unstable

  • Phobias

  • Fearful/easily frightened

  • Frequent colds

  • Hallucinations

  • Hyperactivity

  • Insomnia

  • Intolerance to some protein foods

  • Joint pain

  • Irregular menstrual cycle

  • Low libido

  • Male impotence

  • Migraines

  • Mood swings (severe)

  • Morning nausea

  • Motion sickness

  • Higher activity in the evening than mornings

  • Nervous exhaustion

  • Nervousness

  • Overwhelmed by stressful situations

  • Pale skin, sunburn easily

  • Poor dream recall

  • Poor growth of hair on head, eyebrows, and eyelashes areas

  • Panic attacks

  • Paranoia (paranoid schizophrenia)

  • Pessimism

  • The tendency to skip breakfast, lack of morning appetite

  • Reading disorder

  • Seizures/ Epilepsy

  • Sensitivity to bright light, noises and smells

  • Skin sensitivity/must remove clothes tags

  • Severe inner tension

  • Social withdrawal

  • Substance abuse

  • Temper tantrums

  • Tendency towards iron-deficient anaemia

  • Unusual breath and body odour/ sweet smell

  • White marks on fingernails

You do not need to experience all symptoms to test positive for pyroluria.. You may only have a few pesonality traiits and symptoms.


How do you test for Pyroluria?


There is a simple laboratory test of urine that indicates the number of pyrroles per gram of creatinine.

Patients who complain of anxiety, anger explosion or other mental issues should rule out pyroluria by doing this simple test.


Patients with the appropriate dosage of nutrients report improvement of symptoms within the first few weeks of treatment. 






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